Neuphoria Therapeutics Inc. is a clinical-stage biopharmaceutical company that discovers and develops novel allosteric ion channel modulators for central nervous system disorders. Its lead candidate BNC210, a selective negative allosteric modulator of the α7 receptor, is in development for social anxiety disorder and in Phase 2b for post-traumatic stress disorder. The company also develops BNC101, a monoclonal antibody targeting cancer stem cells that has completed Phase 1, and BNC105 for cancer. Additional programs include NextGen in preclinical development for multiple CNS indications and a Kv3.1/3.2 agonist in preclinical development for cognitive deficits and negative symptoms/social withdrawal in schizophrenia and autism spectrum disorders. It collaborates with Merck & Co., Inc. on α7 receptor positive allosteric modulators for cognitive dysfunction associated with Alzheimer's disease and other CNS conditions. Formerly Bionomics Limited, it changed its name to Neuphoria Therapeutics Inc. in December 2024, was incorporated in 1996, and is based in Burlington, Massachusetts.