← Back

Tango Therapeutics Inc

23.08+204.5%1Y · USD

Tango Therapeutics, Inc. is a precision oncology company focused on discovering and developing drugs for defined patient populations with unmet medical needs. Its pipeline includes methylthioadenosine-cooperative PRMT5 inhibitors: TNG462, in Phase 1/2 clinical trials for pancreatic and lung cancer, and TNG456, a brain-penetrant PRMT5 inhibitor for glioblastoma. It is also developing TNG260, a co-repressor of repressor element-1 silencing transcription inhibitor, designed to reverse the immune evasion effect of STK11 loss-of-function mutations in lung cancer. The company was founded in 2017 and is headquartered in Boston, Massachusetts.

Price · split & dividend adjusted
News & notes moving TNGX
United States
Biotech & Genomic Medicine▼

Tango Therapeutics Posts Wider Q2 Loss as Expenses Climb

Tango Therapeutics reported a second-quarter 2026 loss of 37 cents per share, wider than the Zacks Consensus Estimate of a loss of 31 cents, as higher operating expenses weighed on results. The company had reported a loss of 35 cents per share in the year-ago quarter, and collaboration revenues fell to zero from $3.2 million a year earlier after all remaining deferred revenues under the truncated Gilead collaboration were recognized during 2025. Research and development expenses rose 13% year over year to $37.2 million, driven mainly by higher spending on the vopimetostat and TNG456 clinical programs, while general and administrative expenses nearly doubled to $22.6 million on higher personnel-related costs including share-based compensation. Over the past month the consensus estimate has shifted -10.16%, and the stock carries a Zacks Rank #3 (Hold) with an aggregate VGM Score of F. Shares of Tango Therapeutics have lost about 6.2% since the last earnings report, underperforming the S&P 500.
About megatrends
Biotech & Genomic Medicine › Oncology Therapeutics ▼Capital
TNGX · Capital · Negative Q2 loss of 37 cents per share was wider than expected as R&D and G&A expenses climbed and collaboration revenue fell to zero.
Read original ↗
Zacks Investment Research·25dRead more →
TNGX

Tango Therapeutics Executive Chair Barbara Weber Steps Down

Tango Therapeutics announced that Executive Chairman Dr. Barbara Weber is stepping down from the board to pursue other interests. The clinical-stage precision cancer medicine company expressed gratitude for her vision and leadership. No successor was named in the announcement.
TNGX · · Neutral Executive chair departure without successor creates leadership uncertainty.
Read original ↗
GlobeNewswire·60dRead more →
Biotech & Genomic Medicine▲

Canaccord and Jefferies Raise Tango Therapeutics Price Targets on Vopimetostat Combination Prospects

Canaccord Genuity raised its price target on Tango Therapeutics from $42 to $46 while Jefferies upgraded the stock from Hold to Buy and lifted its target from $27 to $60, citing the potential of vopimetostat combined with KRAS inhibitors. Canaccord's revised model incorporates combined revenues from the therapy in non-small cell lung cancer, while Jefferies highlighted promising data for vopimetostat plus daraxonrasib in pancreatic ductal adenocarcinoma, estimating an opportunity worth more than $4 billion covering 25% to 40% of patients. Tango Therapeutics also recently signed an underwriting agreement for an offering of nearly 18.2 million common shares at $30 per share and pre-funded warrants for over 1.83 million shares at $29.99, expecting net proceeds of around $566.5 million to fund pivotal trials and other corporate needs.
About megatrends
Biotech & Genomic Medicine › Oncology Therapeutics Competition
TNGX · Capital · Positive Analyst price target raises and upgrade on vopimetostat combination prospects
Read original ↗
Insider Monkey·82dRead more →
Biotech & Genomic Medicine▲3

Tango Therapeutics Advances Precision Oncology with MTAP-Targeting Combinations

Tango Therapeutics is emerging as a key test of precision oncology's value in 2026, centered on MTAP-deleted cancers and synthetic lethality. Its lead asset vopimetostat, an MTA-cooperative PRMT5 inhibitor, is being combined with Revolution Medicines' daraxonrasib and zoldonrasib, as well as Erasca's pan-RAS molecular glue ERAS-0015, in MTAP-deleted, RAS-mutant pancreatic cancer. An early signal from the vopimetostat-daraxonrasib arm showed a 92% objective response rate, 100% disease control rate, and 90% six-month progression-free survival rate among 12 evaluable patients, with plans to advance into late-stage development. Vopimetostat is also in monotherapy studies for MTAP-deleted lung cancer, while brain-penetrant TNG456 is in a phase I/II trial for MTAP-deleted solid tumors including glioblastoma, with data expected in 2026. The stock carries a Zacks Rank #3 (Hold) and a Momentum Score of B, though value and growth scores remain weak.
About megatrends
Biotech & Genomic Medicine › Oncology Therapeutics Technology
TNGX · Technology · Positive Tango's vopimetostat combination showed 92% ORR and 90% six-month PFS in pancreatic cancer, advancing its precision oncology pipeline.
RVMD · Demand · Positive Revolution Medicines' daraxonrasib and zoldonrasib are being combined with Tango's vopimetostat, with early data showing high response rates, supporting their clinical development.
ERAS · Demand · Positive Erasca's pan-RAS molecular glue ERAS-0015 is being combined with Tango's vopimetostat in MTAP-deleted pancreatic cancer, potentially expanding its clinical utility.
Read original ↗
Zacks Investment Research·95dRead more →
TNGX▲

Tango Therapeutics Appoints Robert Azelby to Board of Directors

Tango Therapeutics has appointed Robert Azelby to its Board of Directors. Azelby brings more than 30 years of experience in executive management, commercial product launches, and corporate governance, and currently serves on the boards of ADC Therapeutics, Autolus Therapeutics, and Cardinal Health. He previously served as President and CEO of Eliem Therapeutics and as CEO and board member of Alder BioPharmaceuticals. Tango is advancing its investigational PRMT5 inhibitor, Vopimetostat, through late-stage development for pancreatic cancer. Shares of Tango closed Monday at $28.50, up 1.89%, and were trading at $28.49 in the pre-market.
TNGX · Capital · Positive Appointment of experienced executive Robert Azelby to board strengthens governance and strategic oversight.
Read original ↗
RTTNews·104dRead more →