Silo Pharma, Inc. is a developmental-stage biopharmaceutical company. It is developing therapeutics for underserved conditions such as post-traumatic stress disorder (PTSD), stress-induced anxiety disorders, fibromyalgia, and central nervous system (CNS) diseases, focusing on traditional therapies and psychedelic treatments in formulations. Its lead program, SPC-15, is an intranasal treatment targeting PTSD and stress-induced anxiety disorders, while SP-26 is a time-release ketamine-loaded implant for fibromyalgia and chronic pain relief. Two preclinical programs include SPC-14, an intranasal compound for Alzheimer's disease, and SPU-16, a CNS-homing peptide targeting multiple sclerosis (MS). Research and development is conducted through collaborations with Columbia University, Medspray Pharma BV, and the University of Maryland, Baltimore. The company was formerly known as Uppercut Brands, Inc. and changed its name to Silo Pharma, Inc. in September 2020. It was incorporated in 2010 and is based in Sarasota, Florida.