Sana Biotechnology, Inc. is a biotechnology company focused on using engineered cells as medicines in the United States. It develops ex vivo and in vivo cell engineering platforms for therapeutic areas with unmet needs, including type 1 diabetes, B cell mediated autoimmune diseases, and oncology. Its pipeline includes UP421, a HIP-modified allogeneic primary islet cell product in phase 1 for type 1 diabetes; SC451, a HIP-modified stem cell derived pancreatic islet cell therapy in preclinical for type 1 diabetes; and SG293 and SG299, CD8-targeted fusosomes for B cell hematologic malignancies and B cell mediated autoimmune diseases. The company has an option and license agreement with Beam Therapeutics Inc. for CRISPR Cas12b nuclease editing technology, a license agreement with Harvard College for hypoimmune-modified cell intellectual property, and a strategic collaboration with Mayo Clinic for SC451. Formerly FD Therapeutics, Inc., it changed its name to Sana Biotechnology, Inc. in September 2018, was incorporated in 2018, and is headquartered in Seattle, Washington.