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Alector Inc

Alector, Inc. is a clinical-stage biotechnology company that develops therapies to counteract the progression of neurodegeneration in the United States. Its pipeline includes Nivisnebart, an investigational human recombinant monoclonal antibody for prevalent neurodegenerative diseases; AL137, an anti-amyloid beta antibody in preclinical development for Alzheimer's disease; and AL050, a GCase enzyme replacement therapy in preclinical development for Parkinson's disease and Lewy body dementia in patients with GBA1 gene mutations. The company also develops preclinical and research candidates such as AL064, a tau siRNA for Alzheimer's disease and other tauopathies; ADP062-ABC, an alpha-synuclein siRNA for Parkinson's disease; and ADP065-ABC, an NLRP3 siRNA for neurodegenerative conditions. Alector has a strategic collaboration with GlaxoSmithKline plc for the development and commercialization of progranulin-elevating monoclonal antibodies, including Latozinemab and Nivisnebart. Founded in 2013, it is headquartered in South San Francisco, California.

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Biotech & Genomic Medicine▼

Alector stock plummets 13% as GSK terminates neuroscience pact

Alector shares dropped 13% in extended trading after GSK terminated their neuroscience collaboration covering two experimental antibody drugs following clinical setbacks. The decision comes after a late-stage study of latozinemab failed last year and a mid-stage Alzheimer's trial of nivisnebart was discontinued in April. The termination will be effective January 2, 2027. Under the 2021 deal, Alector received $700 million upfront from GSK and could have earned up to $1.5 billion in milestone payments and royalties.
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Biotech & Genomic Medicine › Neuroscience & Neurodegenerative ▼Competition
ALEC · Capital · Negative GSK terminated neuroscience collaboration, ending potential milestone payments and royalties.
GSK.LSE · Technology · Neutral GSK terminated pact after clinical setbacks, but impact on GSK is limited as it cuts losses.
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